Veranstaltung

Enzymes are ideally suited as biocatalysts for the
development of sustainable and environmentally friendly
processes. Due to their high chemo-, regio- and
stereoselectivity and their activity at low temperatures and
ambient pressures, enzymes are currently used in areas
such as pharmaceutical synthesis and fine chemistry.
However, not all enzymes are designed by nature for
efficient application and hence their properties need to be
optimized. Protein engineering is the key method to tailordesign
enzymes, but also to investigate their structurefunction
relationships in basic research.
Due to the rapid development of the tools available for
protein engineering in the past decade, researchers have
the problem of too many choices when trying to engineer a
given enzyme.
This course aims to provide a state-of-the-art overview
about the various methods to allow an efficient and fast
protein engineering. This should enable the participants to
solve their future research problems more easily. The
summer school will cover all modern methods ranging from
rational protein design via focused directed evolution to
pure random mutagenesis in combination with screening or
selection. All methodologies will be presented and
discussed in detail by international speakers active in the
field.
The practicability will be taught in parallel experiments to
ensure that tips and tricks from experienced staff can be
applied "hands-on" by the participants.